PerspectiveStructural Biology

A Glimpse into tmRNA-Mediated Ribosome Rescue

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Science  04 Apr 2003:
Vol. 300, Issue 5616, pp. 72-73
DOI: 10.1126/science.1084034

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Eubacteria use a molecule called tmRNA to rescue ribosomes that stall on mRNA during protein synthesis. In their perspective, Moore et al. discuss new work ( Valle et al.) that uses cryo-electron microscopy to determine the structure of tmRNA in complex with the ribosome. The structure gives insight into how tmRNA is able to function as both a tRNA and a mRNA to release the stalled ribosomes.