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Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling

Science  11 Apr 2003:
Vol. 300, Issue 5617, pp. 332-336
DOI: 10.1126/science.1080585

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Abstract

Glucose modulates many vital processes in photosynthetic plants. Analyses of Arabidopsis glucose insensitive2(gin2) mutants define the physiological functions of a specific hexokinase (HXK1) in the plant glucose-signaling network. HXK1 coordinates intrinsic signals with extrinsic light intensity. HXK1 mutants lacking catalytic activity still support various signaling functions in gene expression, cell proliferation, root and inflorescence growth, and leaf expansion and senescence, thus demonstrating the uncoupling of glucose signaling from glucose metabolism. The gin2 mutants are also insensitive to auxin and hypersensitive to cytokinin. Plants use HXK as a glucose sensor to interrelate nutrient, light, and hormone signaling networks for controlling growth and development in response to the changing environment.

  • * These authors contributed equally to this work.

  • Present address: Department of Genetics and Biochemistry, Clemson University, 100 Jordan Hall, Clemson, SC 29631, USA.

  • Present address: Botany Institute, Academia Sinica, Taipei, Taiwan.

  • § Present address: Department of Life Science, Pohang University of Science and Technology, Pohang 790-784, Korea.

  • || To whom correspondence should be addressed. E-mail: sheen{at}molbio.mgh.harvard.edu

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