An Unstable Liaison

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Science  18 Apr 2003:
Vol. 300, Issue 5618, pp. 442-443
DOI: 10.1126/science.1084468

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It is well established that changes in the pattern of DNA methylation are involved in tumor formation. But whether hypomethylation or hypermethylation is the culprit is questionable. In his Perspective, Lengauer discusses intriguing new findings providing evidence that hypomethylation contributes to genomic instability leading to cancer.