An Overoxidation Journey with a Return Ticket

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Science  25 Apr 2003:
Vol. 300, Issue 5619, pp. 592-594
DOI: 10.1126/science.1084976

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The peroxiredoxins are ubiquitous enzymes that catalyze the reduction of hydrogen peroxide. In their Perspective, Georgiou and Masip discuss some intriguing new details of peroxiredoxin biochemistry that reveal how these enzymes can be simultaneously both antioxidants and modulators of signal transduction ( Wood et al.; Woo et al.).