DATABASE: Turning On the myc

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Science  23 May 2003:
Vol. 300, Issue 5623, pp. 1211
DOI: 10.1126/science.300.5623.1211c

The myc gene is one of the cell's movers and shakers. The well-connected gene not only speeds up cell division, researchers recently recognized, it also turns on genes that rev up metabolism and help power a cancer cell's prodigious reproduction. Keep track of myc's network of genetic contacts and its role in human cancers at this 9-month-old site run by molecular biologist Chi Van Dang of Johns Hopkins University in Baltimore, Maryland. The site's target gene database profiles the 647-and-counting genes that myc governs. Entries specify each gene's function, which method linked it to myc, whether myc turns it up or down, and other info. A second database lists studies that have linked myc to lung, bladder, breast, and other cancers.

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