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The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons

Science  23 May 2003:
Vol. 300, Issue 5623, pp. 1288-1291
DOI: 10.1126/science.1082588

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Abstract

Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alus into new exons, we compiled and analyzed a data set of human exonized Alus. We revealed a mechanism that governs 3′ splice-site selection in these exons during alternative splicing. On the basis of these findings, we identified mutations that activated the exonization of a silent intronic Alu.

  • * These authors contributed equally to this work.

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