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Characterization of Mammalian Selenoproteomes

Science  30 May 2003:
Vol. 300, Issue 5624, pp. 1439-1443
DOI: 10.1126/science.1083516

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Abstract

In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.

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