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Evolution of the Protein Repertoire

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Science  13 Jun 2003:
Vol. 300, Issue 5626, pp. 1701-1703
DOI: 10.1126/science.1085371

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Most proteins have been formed by gene duplication, recombination, and divergence. Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.

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