Fusion of Cells by Flipped SNAREs

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Science  13 Jun 2003:
Vol. 300, Issue 5626, pp. 1745-1749
DOI: 10.1126/science.1084909

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The SNARE (soluble N-ethylmaleimide–sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interact specifically to control and mediate intracellular membrane fusion events. Here, cells expressing the interacting domains of v- and t-SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.

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