Myosin Motors Walk the Walk

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Science  27 Jun 2003:
Vol. 300, Issue 5628, pp. 2045-2046
DOI: 10.1126/science.1087148

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Myosin molecular motors move along actin filaments to drive, for example, muscle contraction or the intracellular trafficking of vesicles. However, it has not been clear whether myosin V moves along actin filaments in a hand-over-hand or inchworm fashion. In their Perspective, Molloy and Veigel explain new work ( Yildiz et al.) that provides evidence in support of the hand-over-hand model for how myosin V walks along actin.