PerspectiveStructural Biology

A Ménage à Trois in Two Configurations

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Science  11 Jul 2003:
Vol. 301, Issue 5630, pp. 177-179
DOI: 10.1126/science.1087734

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The interaction of thrombin with the GpIb-IX-V complex on the surface of platelets is crucial for the formation of blood clots following vascular injury. In a Perspective, Sadler discusses two new crystallographic studies ( Celikel et al., Dumas et al.) that shed new but perhaps conflicting light on this vital interaction.