News of the WeekMedicine

Drug Deals Diabetes a One-Two Punch

Science  18 Jul 2003:
Vol. 301, Issue 5631, pp. 290
DOI: 10.1126/science.301.5631.290

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An enzyme called glucokinase regulates two key functions that fail in diabetics: secretion of insulin by the pancreas and production of glucose by the liver. On page 370, molecular pharmacologists describe how a single oral dose of a glucokinase activator caused blood sugar levels in diabetic mice to plummet by half.