PerspectiveStructural Biology

Breaching the Barrier

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Science  01 Aug 2003:
Vol. 301, Issue 5633, pp. 603-604
DOI: 10.1126/science.1088621

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Summary

There are a huge number of membrane transporter proteins that transport molecules across the impermeable barrier presented by cellular membranes. In their Perspective, Locher et al. discuss a double tour de force ( Abramson et al., Huang et al.), which provide structural determinations of two bacterial transporters, LacY and GlpT, and insights into how they work.