Report

A Conserved Domain in Axonal Targeting of Kv1 (Shaker) Voltage-Gated Potassium Channels

+ See all authors and affiliations

Science  01 Aug 2003:
Vol. 301, Issue 5633, pp. 646-649
DOI: 10.1126/science.1086998

You are currently viewing the abstract.

View Full Text

Abstract

Axonal voltage-gated potassium (Kv1) channels regulate action-potential invasion and hence transmitter release. Although evolutionarily conserved, what mediates their axonal targeting is not known. We found that Kv1 axonal targeting required its T1 tetramerization domain. When fused to unpolarized CD4 or dendritic transferrin receptor, T1 promoted their axonal surface expression. Moreover, T1 mutations eliminating Kvβ association compromised axonal targeting, but not surface expression, of CD4-T1 fusion proteins. Thus, proper association of Kvβ with the Kv1 T1 domain is essential for axonal targeting.

View Full Text

Related Content