Modifying the Message

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Science  15 Aug 2003:
Vol. 301, Issue 5635, pp. 927-928
DOI: 10.1126/science.1088948

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It has long been known that phenotypic variation involves a complex web of interactions with genetic background influencing the expression of genetic variants. In his Perspective, Nadeau describes new work ( Buchner et al.) that identifies a modifier gene and determines how it acts to affect the severity of neuronal defects in med mice.