PerspectiveCell Signaling

β-Arrestin--Not Just for G Protein-Coupled Receptors

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Science  05 Sep 2003:
Vol. 301, Issue 5638, pp. 1338-1339
DOI: 10.1126/science.1089552

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Summary

The-arrestin adaptor proteins are known to mediate the endocytosis of G protein-coupled receptors. In this way, they down-regulate the activated receptors ensuring that they are degraded or recycled within the cell. As Spiegel explains in his Perspective, it now turns out that-arrestins are also important for the endocytosis and down-regulation of a variety of other receptors including Frizzled 4 and TGF--receptors, II and III ( Chen et al., Chen et al.).