Policy ForumMedicine

Stroke--tPA and the Clinic

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Science  19 Sep 2003:
Vol. 301, Issue 5640, pp. 1677
DOI: 10.1126/science.1090270

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Clinical trial results are not always rapidly incorporated into routine medical practice. This Policy Forum describes a variety of barriers that have impeded the more widespread use of thrombolytic therapy (tPA, tissue plasminogen activator) for selected patients with acute ischemic stroke. These barriers are not insurmountable but will require a concerted effort to overcome.