From Molecules to Memory in the Cerebellum

Science  19 Sep 2003:
Vol. 301, Issue 5640, pp. 1682-1685
DOI: 10.1126/science.1090462

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Neuroscientists have long sought to elucidate the molecular underpinnings of the memories needed to learn, for example, a motor task. In his Perspective, Linden discusses new work ( Koekkoek et al.) suggesting that long-term depression in Purkinje cells mediated by protein kinase C signaling is responsible for motor memory in a task called associative eyelid conditioning.