Stout Guards of the Central Nervous System

Science  03 Oct 2003:
Vol. 302, Issue 5642, pp. 65-67
DOI: 10.1126/science.1091256

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Endocannabinoids have paradoxical effects on the mammalian nervous system: Sometimes they block neuronal excitability and other times they augment it. In their Perspective, Mechoulam and Lichtman discuss new work ( Marsicano et al.) showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy.