A Neurexin-Related Protein, BAM-2, Terminates Axonal Branches in C. elegans

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Science  10 Oct 2003:
Vol. 302, Issue 5643, pp. 293-296
DOI: 10.1126/science.1089163

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Neuronal axons connect to multiple target cells through the formation of collateral branches, but the mechanisms that regulate this process are largely unknown. We show that BAM-2, a neurexin-related transmembrane protein, is required for development of VC motoneuron branches in the worm Caenorhabditis elegans. Expression analysis and ectopic expression experiments suggest that BAM-2 functions as a branch termination cue and reveal a mechanism for selective control of branches that sprout off a primary axon.

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