Essays on Science and SocietyEPPENDORF 2003 PRIZE-WINNING ESSAY

Ubiquitin and the Deconstruction of Synapses

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Science  31 Oct 2003:
Vol. 302, Issue 5646, pp. 800-801
DOI: 10.1126/science.1092546

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Summary

The postsynaptic density (PSD) is a macromolecular machine that organizes signal transduction pathways at the postsynaptic membrane. In his essay that won the Eppendorf & Science Prize for Neurobiology, Michael Ehlers discusses how synapse activity regulates changes in PSD composition through ubiquitin-dependent protein turnover.

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