Special Reviews

The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra?

+ See all authors and affiliations

Science  31 Oct 2003:
Vol. 302, Issue 5646, pp. 822-826
DOI: 10.1126/science.1092132

You are currently viewing the abstract.

View Full Text


Genetic factors play a major role in the etiology of adult-onset neurodegenerative and neuropsychiatric disorders. Several highly penetrant genes have been cloned for rare, autosomal-dominant, early-onset forms of neurodegenerative diseases. These genes have provided important insights into the mechanisms of these diseases (often altering neuronal protein processing). However, the genes associated with inherited susceptibility to late-onset neurodegenerative diseases, schizophrenia, and bipolar disorder appear to have smaller effects and are likely to interact with each other (and with nongenetic factors) to modulate susceptibility and/or disease phenotype. Several strategies have recently been applied to address this complexity, leading to the identification of a number of candidate susceptibility loci/genes.

View Full Text

Related Content