Building Cells

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Science  07 Nov 2003:
Vol. 302, Issue 5647, pp. 951
DOI: 10.1126/science.302.5647.951a

In the early stages of fly embryo development, nuclei divide but remain within a single compartment. Subsequently, these 6000 syncytial nuclei are individually packaged into newly constructed cell membranes. Lee et al. show that the tumor suppressor Discs-Large (Dlg), which is known to be involved in the genesis of cell polarity, forms a complex with the membrane protein Strabismus (Stbm), which is involved in planar tissue polarity. In mutant larvae lacking either of these proteins, plasma membrane formation was severely compromised; when either protein was overexpressed, excessive amounts of plasma membranes were induced. The Dlg-Stbm complex appears to recruit intracellular post-Golgi membranes to the cell surface in order to support the growth of new plasma membrane. — SMH

Nature Cell Biol. 10.1038/ncb1055 (2003).

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