Switching Off TCR Signaling

Science  14 Nov 2003:
Vol. 302, Issue 5648, pp. 1162-1163
DOI: 10.1126/science.1092675

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The function of the immunological synapse formed between T cells and antigen presenting cells is still not clear. In a Perspective, Malissen discusses new work that identifies the immunological synapse as important for both enhancing and terminating TCR signaling, and the adaptor protein that is necessary for the termination step ( Lee et al .).