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The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Science  14 Nov 2003:
Vol. 302, Issue 5648, pp. 1218-1222
DOI: 10.1126/science.1086507

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Abstract

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

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