PerspectiveStructural Biology

Nuclear Trafficking

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Science  28 Nov 2003:
Vol. 302, Issue 5650, pp. 1513-1514
DOI: 10.1126/science.1092863

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The transcription factor SREBP-2 is a crucial component in cholesterol metabolism, switching on genes that regulate the synthesis and uptake of cholesterol. To activate these genes, SREBP-2 must be transported from the cytoplasm into the nucleus. In his Perspective, Stewart discusses an analysis of the crystal structure of SREBP-2 bound to its nuclear transport protein, importin-, which sheds new light on SREBP-2 nuclear transport ( Lee et al.).