The Paracaspase Connection

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Science  28 Nov 2003:
Vol. 302, Issue 5650, pp. 1515-1516
DOI: 10.1126/science.1092951

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NF-B is a master transcription factor that is activated by numerous different cellular pathways. In their Perspective, Yu and Lenardo discuss new work published here ( Ruefli-Brasse et al.) and elsewhere that identifies MALT1/ Paracaspase as a key player in activating NF-B in response to antigen receptor signaling in T and B cells.