Microglia: The Enemy Within?

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Science  05 Dec 2003:
Vol. 302, Issue 5651, pp. 1689-1690
DOI: 10.1126/science.1092864

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Unlike other brain structures, the hippocampus is able to produce new neurons throughout adult life. In their Perspective, Kempermann and Neumann discuss intriguing studies published here ( Monje et al.) and elsewhere showing that inflammation induced either by irradiation or lipopolysaccharide blocks hippocampal neurogenesis, which can be alleviated by treatment with nonsteroidal anti-inflammatory drugs.