PerspectiveCell Biology

Smurfing at the Leading Edge

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Science  05 Dec 2003:
Vol. 302, Issue 5651, pp. 1690-1691
DOI: 10.1126/science.1092874

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Cell biologists are only now beginning to unravel how cells maintain their polarity and how this polarity contributes to cell migration. In their Perspective, Jaffe and Hall discuss new research ( Wang et al.) describing how ubiquitination and degradation of Rho GTPase (which is an important regulator of the actin cytoskeleton) results in spatial restriction of Rho at the rear of the cell, an essential step in cellular migration.