Chemical Warfare and Mycobacterial Defense

Science  12 Dec 2003:
Vol. 302, Issue 5652, pp. 1900-1902
DOI: 10.1126/science.1092873

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Part of the reason that Mycobacterium tuberculosis is such a successful pathogen is that it has learned how to survive inside the lysosomes of host macrophages. In their Perspective, Pieters and Ploegh describe one reason for the success of this microbe: Its proteasomes are able to protect mycobacterial proteins against attack by nitric oxide and its derivatives, which are produced inside the macrophage lysosomes ( Darwin et al.).