PerspectiveDevelopmental Biology

Tubulogenesis CLICs into Place

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Science  19 Dec 2003:
Vol. 302, Issue 5653, pp. 2077-2078
DOI: 10.1126/science.1093203

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Organs such as the kidney and vascular system have tubes as their functional units. Vital though such tubes are, little is known about how they are formed during embryonic development. In their Perspective, Paul and Beitel discuss new work in the worm ( Berry et al.) demonstrating that an intracellular chloride channel protein called EXC-4 is required for tube formation.