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A C. elegans CLIC-like Protein Required for Intracellular Tube Formation and Maintenance

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Science  19 Dec 2003:
Vol. 302, Issue 5653, pp. 2134-2137
DOI: 10.1126/science.1087667

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Abstract

The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55–amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.

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