Research Article

Dendrite Development Regulated by CREST, a Calcium-Regulated Transcriptional Activator

Science  09 Jan 2004:
Vol. 303, Issue 5655, pp. 197-202
DOI: 10.1126/science.1089845

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3′,5′-monophosphate (cAMP) response element–binding protein (CREB)–binding protein (CBP) and is expressed in the developing brain. Mice that have a targeted disruption of the crest gene are viable but display defects in cortical and hippocampal dendrite development. Cortical neurons from crest mutant mice are compromised in calcium-dependent dendritic growth. Thus, calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis.

    View Full Text

    Cited By...