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Science  16 Jan 2004:
Vol. 303, Issue 5656, pp. 291
DOI: 10.1126/science.303.5656.291c

Diseases such as leukemia result from glitches in the control of hematopoiesis, the process that generates mature blood cells from stem cells. The new Hematopoietic Promoter Database, or HemoPDB, from Ohio State University gives cancer researchers information on 246 leukemia-and lymphoma-related genes from mice and humans.

HemoPDB records the proteins that switch each gene on and off and the DNA sequences to which these proteins attach. Users can also find out each gene's function and the types of cells in which it is active. The scientists who assembled HemoPDB from the literature and Web sites hope it will help researchers pinpoint other genes that might be involved in blood cell development and disorders.

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