PerspectiveCell Biology

BAR Domains Go on a Bender

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Science  23 Jan 2004:
Vol. 303, Issue 5657, pp. 479-480
DOI: 10.1126/science.1094231

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How do cells make vesicles, a process that requires the bending of membranes? In their Perspective, Lee and Schekman discuss new findings ( Peter et al.) that identify a domain called the BAR domain in proteins, such as amphiphysin and endophilin, that induces the curvature of membranes at different points during vesicle formation.

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