Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II

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Science  13 Feb 2004:
Vol. 303, Issue 5660, pp. 1014-1016
DOI: 10.1126/science.1090839

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The structure of an RNA polymerase II–transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.

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