Microbiology

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Science  13 Feb 2004:
Vol. 303, Issue 5660, pp. 927
DOI: 10.1126/science.303.5660.927b

Uropathogenic forms of the bacterium Escherichia coli can divide and multiply within cells of the bladder in so-called pods (see Reports 4 July 2003 p. 105). Now Justice et al. have been able to observe the development of pods in real time using time-lapse videomicroscopy of infected mouse bladder explants. Four phases of development were observed—first bacteria were nonmotile and grew rapidly within the cytoplasm of the bladder cells. The colonies then developed into a biofilm-like community that filled the cytoplasm. Next the bacteria became motile and migrated from the host cell, finally forming a filamentous bacterial cell type. This developmental strategy appears to be important for the bacteria to evade clearance by leukocytes. — SMH

Proc. Natl. Acad. Sci. U.S.A. 101, 1333 (2004).

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