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Nef and Transcription

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Science  13 Feb 2004:
Vol. 303, Issue 5660, pp. 929
DOI: 10.1126/science.303.5660.929b

The Nef protein encoded by human immunodeficiency virus (HIV) appears to function in pathogenesis through interactions in a signaling complex associated with the T cell receptor. Witte et al. identified an unexpected interaction partner of Nef: the protein Eed (embryonic ectodermal development factor). Eed is a member of the Polycomb group of proteins that regulate differentiation and proliferation of lymphocytes by inhibiting transcription. Expression of Nef caused a transient localization of Eed at the plasma membrane. This recruitment of Eed away from the nucleus might relieve its effects on transcriptional activity. Eed can also associate with the cytoplasmic domain of integrins, and stimulation of integrins causes Eed to move to the plasma membrane. Thus, the HIV Nef protein may function in part by coopting a mechanism for control of transcriptional repression that is normally associated with integrin signaling. — LBR

Mol. Cell 13, 179 (2004).

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