Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus

See allHide authors and affiliations

Science  20 Feb 2004:
Vol. 303, Issue 5661, pp. 1192-1195
DOI: 10.1126/science.1092124

You are currently viewing the abstract.

View Full Text


Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

    View Full Text