PerspectiveMolecular Biology

When a Part Is as Good as the Whole

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Science  27 Feb 2004:
Vol. 303, Issue 5662, pp. 1307-1308
DOI: 10.1126/science.1095483

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One of the biggest bacterial enzymes is RNA polymerase, which synthesizes all of the different types of RNA in bacteria. In their Perspective, deHaseth and Nilsen dissect new work ( Young et al.) that identifies the minimal portion of Escherichia coli RNA polymerase that is capable of inducing promoter melting, a critical step in the initiation of RNA synthesis.