Genetic Control of Cortical Convolutions

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Science  26 Mar 2004:
Vol. 303, Issue 5666, pp. 1983-1984
DOI: 10.1126/science.1096414

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Development of the highly convoluted human cerebral cortex depends on the orchestrated migration of millions of cortical neurons from the brain's ventricular and subventricular zones. In a Perspective, Rakic discusses the identification of a mutation in an orphan G protein-coupled receptor that results in a congenital malformation in which overproduction of cortical neurons results in the appearance of an enlarged number of cortical convolutions ( Piao et al.).