PerspectiveCell Biology

Telomere Wedding Ends in Divorce

See allHide authors and affiliations

Science  02 Apr 2004:
Vol. 304, Issue 5667, pp. 60-62
DOI: 10.1126/science.1096809

You are currently viewing the summary.

View Full Text

Summary

The separation of sister chromatids during mitosis depends on dissociation of proteins called cohesins, which hold the sister chromatids together, prompted by a protease called separase. In their Perspective, Azzalin and Lingner discuss new research (Dynek and Smith) revealing an additional type of cohesion between the ends of sister-chromatid telomeres that requires a separate enzyme called tankyrase 1 for separation during anaphase.