PerspectiveCell Biology

Telomere Wedding Ends in Divorce

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Science  02 Apr 2004:
Vol. 304, Issue 5667, pp. 60-62
DOI: 10.1126/science.1096809

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The separation of sister chromatids during mitosis depends on dissociation of proteins called cohesins, which hold the sister chromatids together, prompted by a protease called separase. In their Perspective, Azzalin and Lingner discuss new research (Dynek and Smith) revealing an additional type of cohesion between the ends of sister-chromatid telomeres that requires a separate enzyme called tankyrase 1 for separation during anaphase.