PerspectiveBiochemistry

Oily Barbarians Breach Ion Channel Gates

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Science  09 Apr 2004:
Vol. 304, Issue 5668, pp. 223-224
DOI: 10.1126/science.1097439

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Summary

It has long been debated whether and how voltage-gated ion channels are affected by the lipid environment of the plasma membrane. In his Perspective, Hilgemann discusses new work ( Oliver et al.) showing that the inactivation of voltage-gated potassium (Kv) channels can be modulated by the lipids PIPand arachidonic acid.