Special Reviews

Bacterial Invasion: The Paradigms of Enteroinvasive Pathogens

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Science  09 Apr 2004:
Vol. 304, Issue 5668, pp. 242-248
DOI: 10.1126/science.1090124

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Invasive bacteria actively induce their own uptake by phagocytosis in normally nonphagocytic cells and then either establish a protected niche within which they survive and replicate, or disseminate from cell to cell by means of an actin-based motility process. The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection.

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