PerspectiveCell Biology

Cutting and Pasting Antigenic Peptides

Science  23 Apr 2004:
Vol. 304, Issue 5670, pp. 525-527
DOI: 10.1126/science.1097508

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Summary

It is well established that antigenic proteins are processed in the proteasome of antigen-presenting cells by simple proteolysis to produce antigenic peptides that can be presented to T cells. As Cresswell explains in his Perspective, two recent papers, published here ( Vigneron et al.) and elsewhere, provide an extra layer of complexity to the story with their revelation that two tumor antigenic peptides were formed by a more complicated splicing process in the proteasome.

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