PerspectiveCell Biology

Cutting and Pasting Antigenic Peptides

See allHide authors and affiliations

Science  23 Apr 2004:
Vol. 304, Issue 5670, pp. 525-527
DOI: 10.1126/science.1097508

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


It is well established that antigenic proteins are processed in the proteasome of antigen-presenting cells by simple proteolysis to produce antigenic peptides that can be presented to T cells. As Cresswell explains in his Perspective, two recent papers, published here ( Vigneron et al.) and elsewhere, provide an extra layer of complexity to the story with their revelation that two tumor antigenic peptides were formed by a more complicated splicing process in the proteasome.