Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

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Science  30 Apr 2004:
Vol. 304, Issue 5671, pp. 743-746
DOI: 10.1126/science.1094561

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A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent cellular response. By acute and local activation of a chemically engineered, light-sensitive phosphocofilin mimic, we demonstrate that cofilin polymerizes actin, generates protrusions, and determines the direction of cell migration. We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor.

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