Zif and the Survival of Memory

Science  07 May 2004:
Vol. 304, Issue 5672, pp. 829-830
DOI: 10.1126/science.1098139

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For new memories to survive, they must first undergo a time-dependent process called consolidation. When memories are retrieved, they become labile and sometimes undergo reconsolidation to retain their permanent status. In their Perspective, Izquierdo and Cammarota discuss two new studies ( Lee et al., Frankland et al.) that identify the protein Zif268 as a crucial factor for memory consolidation and reconsolidation in the hippocampus and anterior cingulate cortex of rodents.