PerspectiveStructural Biology

The p75 NGF Receptor Exposed

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Science  07 May 2004:
Vol. 304, Issue 5672, pp. 833-834
DOI: 10.1126/science.1098110

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Neurotrophins such as nerve growth factor (NGF) are secreted growth factors that are important for neuronal survival and plasticity. In their Perspective, Zampieri and Chao discuss a new study (He and Garcia) that highlights some unusual features about the binding of NGF to the p75 receptor.