The Bell Tolls for Phagosome Maturation

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Science  14 May 2004:
Vol. 304, Issue 5673, pp. 976-977
DOI: 10.1126/science.1098573

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Phagocytosis by cells of the immune system, such as macrophages or neutrophils, is a principal host defense against invading bacteria, but is also important for the clearance of dying cells. In his Perspective, Watts discusses new work (Blander and Medzhitov) showing that activation of the Toll-like receptor signaling pathway by bacteria accelerates the maturation of phagosomes and bacterial degradation.