Continuous Particle Separation Through Deterministic Lateral Displacement

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Science  14 May 2004:
Vol. 304, Issue 5673, pp. 987-990
DOI: 10.1126/science.1094567

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We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40seconds with a resolution of ∼10nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of ∼12%.

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